BDBM50122561 (E)-4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-8-methoxy-quinolin-6-yl]-amide::4-Dimethylamino-but-2-enoic acid [4-(3-bromo-phenylamino)-3-cyano-8-methoxy-quinolin-6-yl]-amide::CHEMBL116857::N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

SMILES COc1cc(NC(=O)\C=C\CN(C)C)cc2c(Nc3cccc(Br)c3)c(cnc12)C#N

InChI Key InChIKey=MPNMKIMGGUGYMJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50122561   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50122561(N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinoli...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122561(N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinoli...)
Affinity DataIC50: 2.88E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122561(N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinoli...)
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50122561(N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinoli...)
Affinity DataIC50: 9.35E+3nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122561(N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinoli...)
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50122561(N-(4-(3-bromophenylamino)-3-cyano-8-methoxyquinoli...)
Affinity DataIC50: 2.88E+6nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article