BDBM50121562 CHEMBL153239::Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-propylcarbamoyl)-2-cyclohexyl-ethyl]-amide

SMILES O=C(N[C@@H](CCc1ccccc1)C#N)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1

InChI Key InChIKey=MXYZRWQQCYFNLZ-UHFFFAOYSA-N

Data  3 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121562   

TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121562(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKd:  0.800nMAssay Description:Equilibrium dissociation constant determined using fluorescence based competitive binding assay towards Cathepsin SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121562(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121562(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKi:  5.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProcathepsin L(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50121562(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKi:  2.54E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCathepsin B(Human)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50121562(Morpholine-4-carboxylic acid [1-(1-cyano-3-phenyl-...)
Affinity DataKi:  7.85E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed