BDBM50121518 CHEMBL428139

SMILES CC(C)(C)NC(=O)[C@@H]1CN(CCN1C[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@@H]3[C@H](O)Cc4ccccc34)Cc5cccnc5

InChI Key InChIKey=CBVCZFGXHXORBI-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50121518   

TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121518(CHEMBL428139)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121518(CHEMBL428139)
Affinity DataEC50:  0.0160nMAssay Description:Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121518(CHEMBL428139)
Affinity DataIC50: 0.190nMAssay Description:Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121518(CHEMBL428139)
Affinity DataEC50:  0.0700nMAssay Description:Agonist activity at full length human GLP1R expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2020
Entry Details Article
PubMed