BDBM50121400 CHEMBL3616752

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O

InChI Key InChIKey=DLSWIYLPEUIQAV-UHFFFAOYSA-N

Data  2 IC50  1 Kd  3 EC50  1 Koff

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50121400   

TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121400(CHEMBL3616752)
Affinity DataIC50: 0.130nMAssay Description:Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121400(CHEMBL3616752)
Affinity DataEC50:  0.00700nMAssay Description:Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121400(CHEMBL3616752)
Affinity DataIC50: 30nMAssay Description:Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121400(CHEMBL3616752)
Affinity DataEC50:  0.0190nMAssay Description:Activation of GLP1R (unknown origin) CRE-bla expressed in CHO-K1 cells assessed as receptor potency incubated for 1 hrs by time resolved fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121400(CHEMBL3616752)
Affinity DataKon:  0.123M-1s-1Assay Description:Binding affinity to GLP1R (unknown origin) assessed as dissociation rate constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121400(CHEMBL3616752)
Affinity DataEC50:  0.0190nMAssay Description:Activation of GLP-1 receptor (unknown origin) expressed in CHO-K1 cells assessed as increase in cAMP accumulation by time-resolved fluorescence reson...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50121400(CHEMBL3616752)
Affinity DataKd:  441nMAssay Description:Binding affinity to GLP-1 receptor (unknown origin) assessed as equlibrium constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed