BDBM50121360 CHEMBL3622109::US9751881, Example 11

SMILES Cc1cc(cnc1N1CCC2(C1)CCN(C[C@H](O)c1ccc3C(=O)OCc3c1C)CC2)C#N

InChI Key InChIKey=CBXKZEUAVSJPRA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50121360   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50121360(CHEMBL3622109 | US9751881, Example 11)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Kir1.1 expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50121360(CHEMBL3622109 | US9751881, Example 11)
Affinity DataIC50: 20nMAssay Description:Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent