BDBM50121212 CHEMBL3622372

SMILES C[C@@H]1COCCN1c1cc(=O)n2CC[C@H](N(Cc3cncc(Cl)c3)c2n1)C(F)(F)F

InChI Key InChIKey=SPDQRCUBFSRAFI-UHFFFAOYSA-N

Data  15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50121212   

TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human mTOR by TR-FRET analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/4/2016
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kdelta by TR-FRET analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/4/2016
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kgamma by TR-FRET analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/4/2016
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kbeta by TR-FRET analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/4/2016
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kalpha by TR-FRET analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/4/2016
Entry Details Article
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human Vps34 by TR-FRET analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
12/4/2016
Entry Details Article
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TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
Curtin University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KC2alpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
7/14/2018
Entry Details Article
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TargetPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Human)
Curtin University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KC2gamma (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
7/14/2018
Entry Details Article
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.20nMAssay Description:Inhibition of Vps34 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
7/14/2018
Entry Details Article
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TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Human)
Curtin University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KC2beta (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/14/2018
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
2/18/2021
Entry Details Article
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 27nMAssay Description:Inhibition of Vps34 in human HeLa cells expressing GFP-FYVEMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

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In Depth
Date in BDB:
2/18/2021
Entry Details Article
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.20nMAssay Description:Inhibition of Vps34 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/18/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 1.20nMAssay Description:Competitive inhibition of recombinant human VPS34 in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2024
Entry Details
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Shandong University

Curated by ChEMBL

LigandBDBM50121212(CHEMBL3622372)Copy SMILESCopy InChI

Affinity DataIC50: 38nMAssay Description:Competitive inhibition of VPS34 (unknown origin) incubated for 15 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2024
Entry Details
Copy Entry DOIPubMed
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