BDBM50121212 CHEMBL3622372

SMILES C[C@@H]1COCCN1c1cc(=O)n2CC[C@H](N(Cc3cncc(Cl)c3)c2n1)C(F)(F)F

InChI Key InChIKey=SPDQRCUBFSRAFI-UHFFFAOYSA-N

Data  16 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50121212   

TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Vps34 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50:  1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataEC50: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 38nMAssay Description:Competitive inhibition of VPS34 (unknown origin) incubated for 15 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.20nMAssay Description:Competitive inhibition of recombinant human VPS34 in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human mTOR by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 27nMAssay Description:Inhibition of Vps34 in human HeLa cells expressing GFP-FYVEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KC2beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Vps34 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KC2gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KC2alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human Vps34 by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kalpha by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kbeta by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kgamma by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
LigandPNGBDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PI3Kdelta by TR-FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed