BDBM50121163 3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-5'-yl)benzonitrile::3-[2'-oxospiro[cyclohexane-1,3'-(2',3'-dihydro-1'H-indole)]-5-yl]benzonitrile::CHEMBL308938

SMILES O=C1Nc2ccc(cc2C11CCCCC1)-c1cccc(c1)C#N

InChI Key InChIKey=LCGYUHWSQNIRBE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121163   

TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121163(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Affinity DataIC50: 15nMAssay Description:Inhibition of 3 nM [3H]R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121163(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Affinity DataIC50: 6.60nMAssay Description:Ability to block progesterone induced alkaline phosphatase activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121163(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity for androgen receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121163(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121163(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Affinity DataIC50: 25nMAssay Description:Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed