BDBM50121062 9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE::9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide::CHEMBL113537

SMILES c1ccc(cc1)NC(=O)CCCCCCC(=O)C(F)(F)F

InChI Key InChIKey=KRCXZGYVOZSCSF-UHFFFAOYSA-N

Data  4 KI  21 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50121062   

TargetHistone deacetylase 8(Human)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HDAC8 assessed as substrate deacetylation using N-acetyl-L-Arg-LHis-L-Lys(epsilon-acetyl)-L-Lys(epsilon-acetyl)-coumarin as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of HDAC2 in human HeLa nuclear extractMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of HDAC1 in human HeLa nuclear extractMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant HDAC11More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human recombinant HDAC10More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of HDAC2 in human K562 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of HDAC1 in human K562 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human recombinant HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human recombinant HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant HDAC7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant HDAC5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant HDAC4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human recombinant HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant HDAC2 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase (HDAC1 and HDAC2)(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) prepared from K562 erythroleukemia cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2018
Entry Details Article
PubMed
TargetAcetylpolyamine amidohydrolase(Mycoplana ramosa (Gram-negative bacterium))
Drexel University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of Mycoplana ramosa acetylpolyamine amidohydrolase assessed as substrate deacetylation using L-Lys(epsilon-acetyl)-coumarin as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataIC50: 6.70E+3nMAssay Description:In vitro inhibitory activity against human histone deacetylase (HDAC) using HeLa nuclear extractMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2018
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to HDAC2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity to HDAC3 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Drexel University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataKi:  7.30nMAssay Description:Binding affinity to HDAC8 (unknown origin) assessed as inhibition constant(ki,1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Ghent University

Curated by ChEMBL
LigandPNGBDBM50121062(9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | ...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to HDAC1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed