BDBM50121040 CHEMBL117928::[(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester

SMILES O=C(N[C@@H](Cc1cccnc1)C(=O)N[C@H]1[C@H]2N(CCS2(=O)=O)C1=O)OCc1ccccc1

InChI Key InChIKey=GYLFZOHLIXAVRJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50121040   

TargetCathepsin S(Human)
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121040([(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,7-trioxo-4lambd...)
Affinity DataIC50: 58nMAssay Description:In vitro Inhibitory activity against Cathepsin S cysteine protease by using Cbz-Val-Arg-AMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121040([(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,7-trioxo-4lambd...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibitory activity of Cbz-Phe-Arg-AMC against Cathepsin B cysteine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121040([(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,7-trioxo-4lambd...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin K cysteine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Rat)
Currently Naeja Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50121040([(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,7-trioxo-4lambd...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed