BDBM50120691 (R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyphenyl)pyrrolidin-1-yl)propanamide::CHEMBL144049::N-Hydroxy-2-[3-methyl-2-oxo-3-(4-phenoxy-phenyl)-pyrrolidin-1-yl]-propionamide

SMILES C[C@@H](N1CC[C@](C)(C1=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO

InChI Key InChIKey=ADBJQPXZUYOOEQ-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50120691   

LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataIC50: 185nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
The M. S. University of Baroda

Curated by ChEMBL
LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataIC50: 185nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataKi: <2.10nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataKi: <2.80nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataKi:  143nMAssay Description:Affinity towards Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed