BDBM50120689 (R)-2-((S)-3-(4-(3,5-bis(trifluoromethyl)benzyloxy)phenyl)-3-methyl-2-oxopyrrolidin-1-yl)-N-hydroxypropanamide::2-{3-[4-(3,5-Bis-trifluoromethyl-benzyloxy)-phenyl]-3-methyl-2-oxo-pyrrolidin-1-yl}-N-hydroxy-propionamide::CHEMBL144320

SMILES C[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1)C(=O)NO

InChI Key InChIKey=WTYPBULLPNGNTN-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50120689   

LigandPNGBDBM50120689((R)-2-((S)-3-(4-(3,5-bis(trifluoromethyl)benzyloxy...)
Affinity DataIC50: 2nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
The M. S. University of Baroda

Curated by ChEMBL
LigandPNGBDBM50120689((R)-2-((S)-3-(4-(3,5-bis(trifluoromethyl)benzyloxy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120689((R)-2-((S)-3-(4-(3,5-bis(trifluoromethyl)benzyloxy...)
Affinity DataKi: >2.00E+3nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120689((R)-2-((S)-3-(4-(3,5-bis(trifluoromethyl)benzyloxy...)
Affinity DataKi: >3.00E+3nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120689((R)-2-((S)-3-(4-(3,5-bis(trifluoromethyl)benzyloxy...)
Affinity DataKi: >5.00E+3nMAssay Description:Affinity towards Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed