BDBM50120688 CHEMBL146896::N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-pyrrolidin-1-yl]-propionamide

SMILES COc1ccc(cc1)[C@]1(C)CCN([C@H](C)C(=O)NO)C1=O

InChI Key InChIKey=JRSHTLSUFIPCSG-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50120688   

LigandPNGBDBM50120688(N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-p...)
Affinity DataIC50: 887nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120688(N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-p...)
Affinity DataKi:  4.80nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120688(N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-p...)
Affinity DataKi:  9nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120688(N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-p...)
Affinity DataKi:  92nMAssay Description:Affinity towards Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed