BDBM50120687 CHEMBL144081::N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionamide

SMILES C[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2ccccc2[N+]([O-])=O)cc1)C(=O)NO

InChI Key InChIKey=UGIVRDOCHMXQLW-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50120687   

LigandPNGBDBM50120687(N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phe...)
Affinity DataIC50: 4nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120687(N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phe...)
Affinity DataKi:  35nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120687(N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phe...)
Affinity DataKi:  66nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120687(N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phe...)
Affinity DataKi: >5.00E+3nMAssay Description:Affinity towards Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed