BDBM50120482 1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexahydropyridine)]-3-ylmethanol::CHEMBL358579

SMILES OCC1OC2(CCN(Cc3ccccc3)CC2)c2ccccc12

InChI Key InChIKey=CLVLPTHZLQBGKF-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50120482   

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institute of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM50120482(1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in guinea pig brain homogenates after 180 mins by solid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Pharmazeutisches Institut Der Universit£T Freiburg

Curated by ChEMBL
LigandPNGBDBM50120482(1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...)
Affinity DataKi:  5.66nMAssay Description:Ability to displace [3H](+)-pentazocine from Sigma opioid receptor type 1 of guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Pharmazeutisches Institut Der Universit£T Freiburg

Curated by ChEMBL
LigandPNGBDBM50120482(1'-benzylspiro[1,3-dihydroisobenzofuran-1,4'-(hexa...)
Affinity DataKi:  1.98E+3nMAssay Description:Ability to displace [3H]ditolylguanidine in the presence of 100 nM (+)-pentazocine from Sigma opioid receptor type 2 of rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed