BDBM501204 US11021511, Compound 4

SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C4OCC3(COP(O)(=O)OC1C2CO)OC4n1cnc2c(N)ncnc12

InChI Key InChIKey=FBWRMEBGHKPPCK-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501204   

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataIC50: 10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [139-379,H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataEC50:  19nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [138-378](Mouse)
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataIC50: 2nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent