BDBM50120069 8-Cyclohexylamino-1,3-diethyl-7-(3-fluoro-4-hydroxy-benzyl)-3,7-dihydro-purine-2,6-dione::CHEMBL108491

SMILES CCn1c2nc(NC3CCCCC3)n(Cc3ccc(O)c(F)c3)c2c(=O)n(CC)c1=O

InChI Key InChIKey=UIOJQKMNQRYQJJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50120069   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120069(8-Cyclohexylamino-1,3-diethyl-7-(3-fluoro-4-hydrox...)
Affinity DataIC50: 0.330nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed