BDBM50119616 CHEMBL3618240

SMILES COc1ncc(Nc2nc3ccc(cn3c2-c2nc(C)nc(N)n2)N2CCN(CC2)C(C)C)cc1F

InChI Key InChIKey=OWFAMDTUROKDJB-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50119616   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50119616(CHEMBL3618240)
Affinity DataIC50: 412nMAssay Description:Inhibition of GST-tagged mTOR (1360 to 2549 residues) (unknown origin) using Ulight 4eBP1 peptide incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119616(CHEMBL3618240)
Affinity DataIC50: 294nMAssay Description:Inhibition of PI3Kalpha in human U87MG cells assessed as reduction in AKT Ser473 phosphorylation incubated for 2 hrs followed by compound wahout by a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
LigandPNGBDBM50119616(CHEMBL3618240)
Affinity DataKi:  6.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by alpha screen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed