BDBM50118491 5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-2,4-dione::CHEMBL422810

SMILES Cc1cn(C\C=C\COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O

InChI Key InChIKey=BHMZJUVAVWRNLN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50118491   

TargetThymidine kinase, cytosolic(Human)
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118491(5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibitory activity against HSV-1 Thymidine kinase in OST-TK-/HSV-1 TK+ cell line in combination with BVAraUMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118491(5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Compound was evaluated for inhibitory effect against phosphorylation of [methyl-3H]dThd by HSV-1 Thymidine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118491(5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory effect against phosphorylation of [methyl-3H]dThd by Thymidine Kinase 2 (TK-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118491(5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibitory concentration against HSV-1 TK (A167Y) catalyzed [3H]-GCV phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118491(5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-...)
Affinity DataIC50: 390nMAssay Description:Inhibitory concentration against HSV-1 TK (WT) catalyzed [3H]-GCV phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118491(5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-...)
Affinity DataIC50: 230nMAssay Description:Inhibitory activity against HSV-1 Thymidine kinase in OST-TK-/HSV-1 TK+ cell line in combination with gancicclovirMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed