BDBM50118490 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine::5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-2,4-dione::CHEMBL101135

SMILES Cc1cn(C\C=C/COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O

InChI Key InChIKey=BHMZJUVAVWRNLN-UHFFFAOYSA-N

Data  1 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50118490   

TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibitory concentration on phosphorylation of [methyl-3H]-dTh by HSV-1 Thymidine KinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDeoxynucleoside kinase(Fruit fly)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of [3H]methyl dThd phosphorylation by Drosophila melanogaster dNKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase 2, mitochondrial(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of [3H]methyl dThd phosphorylation by TK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase(HHV-1)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of [3H]methyl dThd phosphorylation by HSV1 TKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase 2, mitochondrial(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Uncompetitive inhibition of human recombinant mitochondrial thymidine kinase 2 using thymidine as substrate by Lineweaver-Burke plottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory effect against phosphorylation of [methyl-3H]dThd by Thymidine Kinase 2 (TK-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against HSV-1 Thymidine kinase in OST-TK-/HSV-1 TK+ cell line in combination with gancicclovirMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory concentration against HSV-1 TK (A167Y) catalyzed [3H]-GCV phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against HSV-1 Thymidine kinase in OST-TK-/HSV-1 TK+ cell line in combination with BVAraUMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibitory concentration against HSV-1 TK (WT) catalyzed [3H]-GCV phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 4.50E+4nMAssay Description:Compound was evaluated for inhibitory effect against phosphorylation of [methyl-3H]dThd by HSV-1 Thymidine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibitory concentration on phosphorylation of [methyl-3H]-dTh by human Thymidine Kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase, cytosolic(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibitory concentration on phosphorylation of [methyl-3H]-dTh by human Thymidine Kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThymidine kinase 2, mitochondrial(Human)
Instituto De QuíMica MéDica (Csic)

Curated by ChEMBL
LigandPNGBDBM50118490(1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-...)
Affinity DataKi:  500nMAssay Description:Inhibition of TK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed