BDBM501184 US11021493, Example 103

SMILES C[C@]1(CS(=O)(=O)C2(CCC2)C(N)=N1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=YKXJXOBEJFRFKF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 501184   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM501184(US11021493, Example 103)
Affinity DataIC50: 3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM501184(US11021493, Example 103)
Affinity DataIC50: 39nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM501184(US11021493, Example 103)
Affinity DataIC50: 50nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM501184(US11021493, Example 103)
Affinity DataIC50: 9.47E+4nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent