BDBM50117909 CHEMBL278176::N-{2-Benzo[1,3]dioxol-5-yl-2-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-2-propyl-phenoxy]-acetyl}-4-isopropyl-benzenesulfonamide

SMILES CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc23)ccc1OC(C(=O)NS(=O)(=O)c1ccc(cc1)C(C)C)c1ccc2OCOc2c1

InChI Key InChIKey=NTQWAQFOJQQOTK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50117909   

TargetEndothelin receptor type B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50117909(N-{2-Benzo[1,3]dioxol-5-yl-2-[4-(2-ethyl-5,7-dimet...)
Affinity DataIC50: 60nMAssay Description:Compound was evaluated for inhibitory activity against human Endothelin B receptor (ETB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50117909(N-{2-Benzo[1,3]dioxol-5-yl-2-[4-(2-ethyl-5,7-dimet...)
Affinity DataIC50: 24nMAssay Description:Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50117909(N-{2-Benzo[1,3]dioxol-5-yl-2-[4-(2-ethyl-5,7-dimet...)
Affinity DataIC50: 13nMAssay Description:Compound was evaluated for inhibitory activity against human Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50117909(N-{2-Benzo[1,3]dioxol-5-yl-2-[4-(2-ethyl-5,7-dimet...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetEndothelin receptor type B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50117909(N-{2-Benzo[1,3]dioxol-5-yl-2-[4-(2-ethyl-5,7-dimet...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human endothelin B (ETB) receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50117909(N-{2-Benzo[1,3]dioxol-5-yl-2-[4-(2-ethyl-5,7-dimet...)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at endothelin receptor subtype AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50117909(N-{2-Benzo[1,3]dioxol-5-yl-2-[4-(2-ethyl-5,7-dimet...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at type 1 angiotensin 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed