BDBM50117900 3-Chloro-2-methyl-N-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzenesulfonamide; hydrochloride (BVT.2733)::CHEMBL463978::CHEMBL553071

SMILES CN1CCN(CC1)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1

InChI Key InChIKey=YDPRNGAPPNPYQQ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50117900   

Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 96nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 96nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Ability to convert [3H]cortisol to the tritium labeled cortisone in the presence of human 11 beta hydroxysteroid dehydrogenase type 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 96nMAssay Description:In vitro inhibitory activity against mouse 11 beta hydroxysteroid dehydrogenase type 1 using scintillation proximity assay (SPA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 3.34E+3nMAssay Description:In vitro inhibitory activity against human 11 beta hydroxysteroid dehydrogenase type 1 using scintillation proximity assay (SPA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of human 11beta-HSD1 using steroid as substrate incubated for 20 to 30 mins by microplate fluorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 96nMAssay Description:Inhibition of mouse 11beta-HSD1 using steroid as substrate incubated for 20 to 30 mins by microplate fluorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed