BDBM50117786 CHEMBL87071::N-(2-Amino-ethyl)-N-(4'-chloro-biphenyl-4-ylmethyl)-2-[2-(4-fluoro-benzylsulfanyl)-5-(1-methyl-1H-pyrazol-4-ylmethyl)-4-oxo-4H-pyrimidin-1-yl]-acetamide

SMILES Cn1cc(Cc2cn(CC(=O)N(CCN)Cc3ccc(cc3)-c3ccc(Cl)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1

InChI Key InChIKey=FNUFKVJAONMVTK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50117786   

TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117786(N-(2-Amino-ethyl)-N-(4'-chloro-biphenyl-4-ylmethyl...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of cytochrome P450 3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlatelet-activating factor acetylhydrolase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117786(N-(2-Amino-ethyl)-N-(4'-chloro-biphenyl-4-ylmethyl...)
Affinity DataIC50: 2nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed