BDBM50117710 8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-3-isobutyl-3,7-dihydro-purine-2,6-dione::CHEMBL314981

SMILES CCOc1ccc(cc1-c1nc2n(CC(C)C)c(=O)[nH]c(=O)c2[nH]1)S(=O)(=O)N1CCN(C)CC1

InChI Key InChIKey=ISAZQINXKTVKTG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50117710   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117710(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50: 315nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117710(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human platelet Phosphodiesterase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50117710(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of bovine heart Phosphodiesterase 1 (PDE1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed