BDBM50117501 CHEMBL3613623

SMILES COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(CC2)c2ncnc3[nH]c(C)c(C)c23)c1

InChI Key InChIKey=RKAKGPYRNHXPDK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50117501   

TargetLIM domain kinase 1(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50117501(CHEMBL3613623)
Affinity DataIC50: 26nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
LigandPNGBDBM50117501(CHEMBL3613623)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50117501(CHEMBL3613623)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ROCK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50117501(CHEMBL3613623)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50117501(CHEMBL3613623)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AKT1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50117501(CHEMBL3613623)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant LIMK1 in presence of ATP cofilin as substrate at 25 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50117501(CHEMBL3613623)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ROCK2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed