BDBM50117368 4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carboxylic acid (4-isopropoxy-phenyl)-amide::CHEMBL444064

SMILES COc1cc2c(ncnc2cc1OCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1

InChI Key InChIKey=VNNNWWNREQUYDU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50117368   

TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117368(4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazoli...)
Affinity DataIC50: 170nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117368(4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazoli...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117368(4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazoli...)
Affinity DataIC50: 110nMAssay Description:Inhibition of chimeric PDGF receptor with c-kit cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117368(4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazoli...)
Affinity DataIC50: 70nMAssay Description:Inhibition of chimeric PDGF receptor with FLT-3 cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117368(4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazoli...)
Affinity DataIC50: 3.43E+3nMAssay Description:Inhibition of chimeric PDGF receptor with CSF-1R cytoplasmic domain phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50117368(4-[6-Methoxy-7-(2-piperidin-1-yl-ethoxy)-quinazoli...)
Affinity DataIC50: 250nMAssay Description:Inhibition of wild type Platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed