BDBM50116515 CHEMBL3609729

SMILES Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1

InChI Key InChIKey=MIQNXKWDQRNHAU-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50116515   

TargetMetabotropic glutamate receptor 4(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116515(CHEMBL3609729)
Affinity DataEC50:  4nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Rat)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116515(CHEMBL3609729)
Affinity DataEC50:  9nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50116515(CHEMBL3609729)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50116515(CHEMBL3609729)
Affinity DataEC50:  1.20E+3nMAssay Description:Positive allosteric modulation of rat mGlu8 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116515(CHEMBL3609729)
Affinity DataEC50:  52nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116515(CHEMBL3609729)
Affinity DataEC50:  52nMAssay Description:Positive allosteric modulation of mGluR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50116515(CHEMBL3609729)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50116515(CHEMBL3609729)
Affinity DataEC50:  1.20E+3nMAssay Description:Positive allosteric modulation of mGluR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed