BDBM50115998 3-[(Benzyl-methyl-amino)-methyl]-8-(2,6-difluoro-benzyl)-2-[4-(3-ethyl-ureido)-phenyl]-5-oxo-5,8-dihydro-imidazo[1,2-a]pyrimidine-6-carboxylic acid ethyl ester::CHEMBL292291::ethyl 8-(2,6-difluorobenzyl)-3-((benzyl(methyl)amino)methyl)-2-(4-(3-ethylureido)phenyl)-5-oxo-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylate

SMILES CCNC(=O)Nc1ccc(cc1)-c1nc2n(Cc3c(F)cccc3F)cc(C(=O)OCC)c(=O)n2c1CN(C)Cc1ccccc1

InChI Key InChIKey=YCJOYRXLFOTOAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50115998   

TargetGonadotropin-releasing hormone receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115998(ethyl 8-(2,6-difluorobenzyl)-3-((benzyl(methyl)ami...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of specific [125I]leuprorelin binding to the cloned human LHRH receptor expressed in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50115998(ethyl 8-(2,6-difluorobenzyl)-3-((benzyl(methyl)ami...)
Affinity DataIC50: 71nMAssay Description:Antagonist activity at human GnRHR expressed in CHO cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed