BDBM50115895 CHEMBL303367::N-(4-Carbamimidoyl-phenyl)-3-chloro-2-hydroxy-benzamide

SMILES NC(=N)c1ccc(NC(=O)c2cccc(Cl)c2O)cc1

InChI Key InChIKey=FKUAJSCZSYQJSF-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50115895   

TargetKallikrein-1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50115895(N-(4-Carbamimidoyl-phenyl)-3-chloro-2-hydroxy-benz...)
Affinity DataIC50: 631nMAssay Description:Inhibition of recombinant human N-terminal his-tagged KLK1 (19 to 262 residues) expressed in baculovirus infected sf9 insect cells using R110 labelle...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetKallikrein-5(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50115895(N-(4-Carbamimidoyl-phenyl)-3-chloro-2-hydroxy-benz...)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of recombinant human FLAG-tagged KLK5 expressed in baculovirus infected sf9 insect cells using (Tos-Gly-Pro-Arg)2[R110].2TFA as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Celera

Curated by ChEMBL
LigandPNGBDBM50115895(N-(4-Carbamimidoyl-phenyl)-3-chloro-2-hydroxy-benz...)
Affinity DataKi:  600nMAssay Description:Inhibition of urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Celera

Curated by ChEMBL
LigandPNGBDBM50115895(N-(4-Carbamimidoyl-phenyl)-3-chloro-2-hydroxy-benz...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Celera

Curated by ChEMBL
LigandPNGBDBM50115895(N-(4-Carbamimidoyl-phenyl)-3-chloro-2-hydroxy-benz...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Celera

Curated by ChEMBL
LigandPNGBDBM50115895(N-(4-Carbamimidoyl-phenyl)-3-chloro-2-hydroxy-benz...)
Affinity DataKi:  1.50E+3nMAssay Description:Activation of plasminogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed