BDBM50115581 (Z)-2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-enoic acid::2-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-but-2-enoic acid::CHEMBL108423::CHEMBL185721::CHEMBL573638

SMILES OC(=O)C(=O)CC(=O)c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=NHQPPCOWPBXWBJ-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50115581   

TargetIntegrase(Human immunodeficiency virus type 1)
Università

Curated by ChEMBL
LigandPNGBDBM50115581(CHEMBL108423 | CHEMBL185721 | (Z)-2-Hydroxy-4-oxo-...)
Affinity DataIC50: 1.14E+4nMAssay Description:Strand transfer inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA excision repair protein ERCC-5(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50115581(CHEMBL108423 | CHEMBL185721 | (Z)-2-Hydroxy-4-oxo-...)
Affinity DataIC50: 1.87E+3nMAssay Description:Concentration required for 50% inhibition of Xeroderma pigmentosum GMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFlap endonuclease 1(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50115581(CHEMBL108423 | CHEMBL185721 | (Z)-2-Hydroxy-4-oxo-...)
Affinity DataIC50: 1.75E+3nMAssay Description:Concentration required for 50% inhibition of Flap endonuclease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Università

Curated by ChEMBL
LigandPNGBDBM50115581(CHEMBL108423 | CHEMBL185721 | (Z)-2-Hydroxy-4-oxo-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory effect on strand transfer of proximal DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Università

Curated by ChEMBL
LigandPNGBDBM50115581(CHEMBL108423 | CHEMBL185721 | (Z)-2-Hydroxy-4-oxo-...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibitory effect on strand transfer of proximal DNA into host DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Università

Curated by ChEMBL
LigandPNGBDBM50115581(CHEMBL108423 | CHEMBL185721 | (Z)-2-Hydroxy-4-oxo-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory effect on 3'-processing(3'-P) of proximal DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50115581(CHEMBL108423 | CHEMBL185721 | (Z)-2-Hydroxy-4-oxo-...)
Affinity DataEC50:  1.45E+3nMAssay Description:Plaque growth inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50115581(CHEMBL108423 | CHEMBL185721 | (Z)-2-Hydroxy-4-oxo-...)
Affinity DataKi:  280nMAssay Description:Binding affinity to PA N-terminal domain (Competitive)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed