BDBM50115104 (pyridin-2-ylamino)methylenediphosphonic acid::2-[(Bis-phosphono-methyl)-amino]-pyridinium::2-{[hydrogen phosphonato(phosphonato)methyl]amino}pyridin-1-ium::CHEMBL291736::[(2-pyridinylamino)methylene]-1,1-bisphosphonate::[Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic acid::[Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic acid(NE11807)

SMILES OP(O)(=O)C(Nc1ccccn1)P(O)(O)=O

InChI Key InChIKey=OEAFYMDEEMRBOS-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50115104   

TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataIC50: 166nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataIC50: 11.7nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataIC50: 85nMAssay Description:Inhibition of human His6-tagged recombinant FPPS expressed in Escherichia coli BL21(DE3) using GPP and [3H]IPP as substrate incubated for 5 mins prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataIC50: 209nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataIC50: 85nMAssay Description:Inhibition of human recombinant N-terminal-His6 tagged FPPS expressed in Escherichia coli BL21 using [14C]IPP and GPP as substrate incubated for 10 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataKi:  20nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50115104([Phosphono-(pyridin-2-ylamino)-methyl]-phosphonic ...)
Affinity DataKi:  29.1nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed