BDBM50114974 2-Nitro-N-(4-{[(1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-amino]-methyl}-cyclohexylmethyl)-benzenesulfonamide::2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl)methylamino)methyl)cyclohexyl)methyl)benzenesulfonamide::CHEMBL299879

SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1

InChI Key InChIKey=ISSSVYKMIIAPTH-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50114974   

TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50114974(2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of Trypanosoma cruzi cruzain by quantitative high throughput screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50114974(2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi cruzain by Flexstation microplate spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50114974(2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl...)
Affinity DataKi:  8nMAssay Description:Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 5(Rat)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50114974(2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl...)
Affinity DataKi:  18nMAssay Description:Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with rat Neuropeptide Y receptor type 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50114974(2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl...)
Affinity DataKi:  63nMAssay Description:Binding affinity against cloned human Dopamine receptor D2 was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50114974(2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl...)
Affinity DataKi:  100nMAssay Description:Bnding affinity against cloned human Alpha-2C adrenergic receptor was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50114974(2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl...)
Affinity DataKi:  1.60E+4nMAssay Description:Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Rat)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50114974(2-nitro-N-((4-(((1,2,3,4-tetrahydronaphthalen-2-yl...)
Affinity DataKi:  2.20E+4nMAssay Description:Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with Neuropeptide Y receptor type 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed