BDBM50114669 (1E)-1-(3-methoxyphenyl)ethan-1-one thiosemicarbazone::CHEMBL92579

SMILES COc1cccc(c1)C(C)=NNC(N)=S

InChI Key InChIKey=KSFGISBKYIAEAI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50114669   

TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114669((1E)-1-(3-methoxyphenyl)ethan-1-one thiosemicarbaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114669((1E)-1-(3-methoxyphenyl)ethan-1-one thiosemicarbaz...)
Affinity DataIC50: 1.48E+6nMAssay Description:Inhibition of epimastigote form of Trypanosoma cruzi Tulahuen 2 cruzain assessed as reduction in 7-amino-4-methylcoumarin release incubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114669((1E)-1-(3-methoxyphenyl)ethan-1-one thiosemicarbaz...)
Affinity DataIC50: 1.47E+6nMAssay Description:Inhibition of epimastigote form of Trypanosoma cruzi Tulahuen 2 cruzain assessed as reduction in 7-amino-4-methylcoumarin release incubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114669((1E)-1-(3-methoxyphenyl)ethan-1-one thiosemicarbaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen 2 cruzain incubated for 5 mins folllowed by Z-Phe-Arg-AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114669((1E)-1-(3-methoxyphenyl)ethan-1-one thiosemicarbaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen 2 cruzain incubated for 5 mins folllowed by Z-Phe-Arg-AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed