BDBM50114622 (1E)-1-(3-chlorophenyl)propan-1-one thiosemicarbazone::CHEMBL90866

SMILES CCC(=NNC(N)=S)c1cccc(Cl)c1

InChI Key InChIKey=MKKISLULTIRJOZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50114622   

TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114622((1E)-1-(3-chlorophenyl)propan-1-one thiosemicarbaz...)
Affinity DataIC50: 220nMAssay Description:Inhibitory activity against Trypanosoma cruzi cathepsin L-like protease (cruzain) was determined using purified recombinant proteinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114622((1E)-1-(3-chlorophenyl)propan-1-one thiosemicarbaz...)
Affinity DataIC50: 2.34E+4nMAssay Description:Inhibition of epimastigote form of Trypanosoma cruzi Tulahuen 2 cruzain assessed as reduction in 7-amino-4-methylcoumarin release incubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114622((1E)-1-(3-chlorophenyl)propan-1-one thiosemicarbaz...)
Affinity DataIC50: 2.32E+4nMAssay Description:Inhibition of epimastigote form of Trypanosoma cruzi Tulahuen 2 cruzain assessed as reduction in 7-amino-4-methylcoumarin release incubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114622((1E)-1-(3-chlorophenyl)propan-1-one thiosemicarbaz...)
Affinity DataIC50: 219nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen 2 cruzain incubated for 5 mins folllowed by Z-Phe-Arg-AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114622((1E)-1-(3-chlorophenyl)propan-1-one thiosemicarbaz...)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Tulahuen 2 cruzain incubated for 5 mins folllowed by Z-Phe-Arg-AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50114622((1E)-1-(3-chlorophenyl)propan-1-one thiosemicarbaz...)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzipain using Z-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed