BDBM50113878 5-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-2-methoxy-N,N-dimethyl-benzamide::CHEMBL83106

SMILES COc1ccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(C)c2F)cc1C(=O)N(C)C

InChI Key InChIKey=GAEBEPXLMSRMNB-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50113878   

TargetSerine protease 1(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50113878(5-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  450nMAssay Description:Inhibitory constant against bovine trypsin for general specificity against serine proteasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50113878(5-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human Coagulation factor X was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50113878(5-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50113878(5-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-meth...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibitory constant against human coagulation factor II (thrombin) for selectivity within coagulation cascadeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed