BDBM50113863 3-[3,5-Difluoro-6-(3-isopropoxy-phenoxy)-4-methyl-pyridin-2-yloxy]-benzamidine::CHEMBL419661

SMILES CC(C)Oc1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(C)c2F)c1

InChI Key InChIKey=HEHAHFSXWKGXJN-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50113863   

TargetCoagulation factor X(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50113863(3-[3,5-Difluoro-6-(3-isopropoxy-phenoxy)-4-methyl-...)
Affinity DataKi:  620nMAssay Description:Inhibition of human Coagulation factor X was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50113863(3-[3,5-Difluoro-6-(3-isopropoxy-phenoxy)-4-methyl-...)
Affinity DataKi:  620nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50113863(3-[3,5-Difluoro-6-(3-isopropoxy-phenoxy)-4-methyl-...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory constant against bovine trypsin for general specificity against serine proteasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50113863(3-[3,5-Difluoro-6-(3-isopropoxy-phenoxy)-4-methyl-...)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibitory constant against human coagulation factor II (thrombin) for selectivity within coagulation cascadeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed