BDBM50113835 4-Fluoro-benzylamine::4-fluorobenzylamine::CHEMBL12392::Integrase inhibitor, R1{2}

SMILES NCc1ccc(F)cc1

InChI Key InChIKey=IIFVWLUQBAIPMJ-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50113835   

TargetGag-Pol polyprotein(HIV-1)
Bristol-Myers Squibb

LigandPNGBDBM50113835(Integrase inhibitor, R1{2} | CHEMBL12392 | 4-fluor...)
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition assay using HIV-1 integrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2013
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
Pharmakea

Curated by ChEMBL
LigandPNGBDBM50113835(Integrase inhibitor, R1{2} | CHEMBL12392 | 4-fluor...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50113835(Integrase inhibitor, R1{2} | CHEMBL12392 | 4-fluor...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of N-terminal His6-tagged KAT8 catalytic domain (125 to 458 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using SGRGK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2020
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50113835(Integrase inhibitor, R1{2} | CHEMBL12392 | 4-fluor...)
Affinity DataKd:  4.27E+5nMAssay Description:Binding affinity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50113835(Integrase inhibitor, R1{2} | CHEMBL12392 | 4-fluor...)
Affinity DataKi:  430nMAssay Description:Binding affinity against bovine trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed