BDBM50113629 CHEMBL3604632

SMILES Cc1cc(c(cc1C2CCN(CC2)C)OC(C)C)Nc3ncc(c(n3)Nc4cn(nc4S(=O)(=O)C(C)C)C)Cl

InChI Key InChIKey=CNIWZQPSVDYFSY-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50113629   

TargetALK tyrosine kinase receptor(Human)
Beijing Pearl Biotech

Curated by ChEMBL
LigandPNGBDBM50113629(CHEMBL3604632)
Affinity DataIC50: 8nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) using TK substrate-biotin incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Beijing Pearl Biotech

Curated by ChEMBL
LigandPNGBDBM50113629(CHEMBL3604632)
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human recombinant ALK using TK substrate-biotin incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)