BDBM50113628 CHEMBL431511::[5-(4-Fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanyl]-acetic acid methyl ester

SMILES COC(=O)CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1

InChI Key InChIKey=SHLGVUBRPWNMLF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50113628   

TargetC-X-C chemokine receptor type 1/2(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113628([5-(4-Fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanyl...)
Affinity DataIC50: 42nMAssay Description:Inhibition against GRO-alpha driven human neutrophil chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113628([5-(4-Fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanyl...)
Affinity DataIC50: 32nMAssay Description:Displacement of [125I]IL-8 from CHO cell membranes expressing human CX3C chemokine receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113628([5-(4-Fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanyl...)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at CXCR2 in human neutrophils assessed as reduction in GRO-alpha mediated chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed