BDBM50113420 CHEMBL418231::{4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-4-yl)-ethyl]-phenyl}-acetic acid

SMILES OC(=O)Cc1ccc(cc1)C(Cc1cc[n+]([O-])cc1)c1ccc(OC(F)F)c(OC(F)F)c1

InChI Key InChIKey=ZEYKKDIJNGWYAA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50113420   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50113420({4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-py...)
Affinity DataIC50: 53nMAssay Description:Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50113420({4-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-py...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed