BDBM50113413 4-[2-(4-Chloro-phenyl)-2-(3-cyclopentyloxy-2-fluoro-4-methoxy-phenyl)-ethyl]-pyridine::CHEMBL284479

SMILES COc1ccc(C(Cc2ccncc2)c2ccc(Cl)cc2)c(F)c1OC1CCCC1

InChI Key InChIKey=IZHRHJLGDDERDG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50113413   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50113413(4-[2-(4-Chloro-phenyl)-2-(3-cyclopentyloxy-2-fluor...)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibitory concentration of compound against LPS- induced TNF-alpha production in whole human blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50113413(4-[2-(4-Chloro-phenyl)-2-(3-cyclopentyloxy-2-fluor...)
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration against human PDE4A isoform using a construct representing the common region of spliced variants expressed as GST-fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed