BDBM50113342 CHEMBL518383

SMILES c1cc(c(c(c1)F)C(=O)Nc2c[nH]nc2C(=O)Nc3ccc(cc3)F)F

InChI Key InChIKey=BDRDBXXWQDFXEC-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50113342   

LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) by radiometric filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 3nMAssay Description:Inhibition of C-terminal His6-tagged human full length CDK2/N-terminal GST-tagged human full length Cyclin A using histone H1 and [gamma-32P]-ATP inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length GST-tagged human CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length GST-tagged human CDK2/Cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 14nMAssay Description:Inhibition of CDK1/cyclin B1 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK2/cyclin A2 (unknown origin) using FAM-labeled peptide and ATP as substrate preincubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 2.95E+4nMAssay Description:Inhibition of recombinant human full length CDK1/cyclin A2 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 9.52E+3nMAssay Description:Inhibition of recombinant human full length CDK2/cyclin A2 incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK4/cyclin D1 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK6/cyclin D3 incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology)

Curated by ChEMBL
LigandPNGBDBM50113342(CHEMBL518383)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant human full length CDK7/cyclin H1 expressed in Sf9 cells incubated for 10 mins by ADP-Glo reagent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed