BDBM50113031 (2R,5R)-1-[4-(2-Cyano-benzyloxy)-benzenesulfonyl]-5-hydroxy-piperidine-2-carboxylic acid hydroxyamide::CHEMBL28139

SMILES ONC(=O)[C@H]1CC[C@@H](O)CN1S(=O)(=O)c1ccc(OCc2ccccc2C#N)cc1

InChI Key InChIKey=PBIRCNBIZATFIL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50113031   

LigandPNGBDBM50113031((2R,5R)-1-[4-(2-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 39nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113031((2R,5R)-1-[4-(2-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113031((2R,5R)-1-[4-(2-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed