BDBM50112829 CHEMBL3609516

SMILES CC(C)(C)c1nc-2c(CCc3nc(NC(=O)N4CCC[C@@]4(C)C(N)=O)sc-23)s1

InChI Key InChIKey=WHJMFYBWPAIUAU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50112829   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112829(CHEMBL3609516)
Affinity DataIC50: 720nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using phosphatidylinositol as substrate preincubated for 15 mins followed by ATP addition measured after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112829(CHEMBL3609516)
Affinity DataIC50: 28nMAssay Description:Inhibition of N-terminal myristoylated human PI3Kalpha expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112829(CHEMBL3609516)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of N-terminal myristoylated human PI3Kbeta expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112829(CHEMBL3609516)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of N-terminal myristoylated human PI3Kgamma expressed in Rat1 cells assessed as inhibition of Akt phosphorylatuion at Ser473 by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50112829(CHEMBL3609516)
Affinity DataIC50: 8nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol as substrate preincubated for 15 mins followed by ATP addition measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2016
Entry Details Article
PubMed