BDBM50112377 1-(3-Chloro-phenyl)-4-[3-(4'-trifluoromethyl-biphenyl-4-ylmethyl)-3H-imidazol-4-ylmethyl]-piperazin-2-one::CHEMBL23939

SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1

InChI Key InChIKey=DISVQWQQQWMFSB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112377   

LigandPNGBDBM50112377(1-(3-Chloro-phenyl)-4-[3-(4'-trifluoromethyl-biphe...)
Affinity DataIC50: 29nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112377(1-(3-Chloro-phenyl)-4-[3-(4'-trifluoromethyl-biphe...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112377(1-(3-Chloro-phenyl)-4-[3-(4'-trifluoromethyl-biphe...)
Affinity DataIC50: 140nMAssay Description:Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]GGPP into a biotinylated peptide corresponding to the C-term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed