BDBM50112374 4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1-(3-chloro-phenyl)-piperazin-2-one::CHEMBL23135

SMILES Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)-c2ccccc2)CC1=O

InChI Key InChIKey=XYYAXYGYXCQAEJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50112374   

LigandPNGBDBM50112374(4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1...)
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in v-Ha-ras-transformed Rat1 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112374(4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1...)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]GGPP into a biotinylated peptide corresponding to the C-term...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50112374(4-(3-Biphenyl-4-ylmethyl-3H-imidazol-4-ylmethyl)-1...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed