BDBM50112266 CHEMBL3608763

SMILES C(N1CCC(CC1)c1[nH]ncc1Cc1ccccc1)c1ccncc1

InChI Key InChIKey=DZLOTZYSSWSJCR-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50112266   

TargetC-C chemokine receptor type 5(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of CCR5 assessed as reduction in fusion of effector cells expressing JRFL envelope (CCR5-tropic/CD4-dependent) with human HeLa-C14 target ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataEC50:  7.00E+4nMAssay Description:Inhibition of CXCR4 assessed as reduction in fusion of human HeLa/67 as target cells expressing CD4, CCR5, and CXCR4) and Lai envelope-expressing eff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataEC50:  5.20E+4nMAssay Description:Inhibition of CXCR4 assessed as reduction in fusion of human ACTOne-X4 cells as target cells expressing only CXCR4) with effector cells expressing HI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CXCR4 in human Jurkat cells assessed as reduction in HIV-Nef-M1-induced mitochondrial membrane depolarization at 0.01 to 100 uM by JC1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
Emory University

Curated by ChEMBL
LigandPNGBDBM50112266(CHEMBL3608763)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity against CXCR4 (unknown origin) by Ca2+ flux GPCR signaling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMed