BDBM50112235 3-(4-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2,3']bipyridinyl-5-carboxylic acid methyl ester::CHEMBL291335

SMILES COC(=O)c1cc(-c2ccc(OC)cc2)c(-c2cccnc2)n(C)c1=O

InChI Key InChIKey=YKVBFMDDXCMYHI-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50112235   

TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112235(3-(4-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2...)
Affinity DataKi:  73nMAssay Description:Binding affinity by displacement of [3H]Ro-151788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112235(3-(4-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2...)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]Ro-151788 from human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112235(3-(4-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2...)
Affinity DataKi: >667nMAssay Description:Inhibition of [3H]Ro-151788 binding to human GABA A receptor (alpha-5-beta-3-gamma-2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112235(3-(4-Methoxy-phenyl)-1-methyl-6-oxo-1,6-dihydro-[2...)
Affinity DataKi:  680nMAssay Description:Displacement of [3H]Ro-151788 from human GABA-A receptor alpha-1-beta-3-gamma-2 subunits expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed