BDBM501114 (S)-7-((6-(3- (dimctliylami- no)azetidin-1- yl)-5- (tetrahydrofur- an-3-yl)pyridin- 2-yl)amino)-4- (7-fluoroimidazo [1,2-a]pyridin-3- yl)isoindolin- 1-one::US11021481, Compound I-786::US11078201, Compound I-786::US11548890, Compound I-786

SMILES CN(C)C1CN(C1)c1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@H]1CCOC1

InChI Key InChIKey=JRBHJMXCXNYEQJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 501114   

LigandPNGBDBM501114(US11021481, Compound I-786 | (S)-7-((6-(3- (dimctl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501114(US11021481, Compound I-786 | (S)-7-((6-(3- (dimctl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM501114(US11021481, Compound I-786 | (S)-7-((6-(3- (dimctl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM501114(US11021481, Compound I-786 | (S)-7-((6-(3- (dimctl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM501114(US11021481, Compound I-786 | (S)-7-((6-(3- (dimctl...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent