BDBM50111373 CHEMBL3604889

SMILES C[C@@H]1C(=O)N(c2cnc(nc2N1CCC(C)C)Nc3cc(c(c(c3)F)O)F)C

InChI Key InChIKey=DTEKTGDVSARYDS-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50111373   

TargetRibosomal protein S6 kinase alpha-3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111373(CHEMBL3604889)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRibosomal protein S6 kinase alpha-3(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50111373(CHEMBL3604889)
Affinity DataEC50:  500nMAssay Description:Inhibition of RSK2 in mouse BAF cells expressing activated FGFR assessed as reduction of YB1 phosphorylation at Ser102 by electochemiluminescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase VRK2(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50111373(CHEMBL3604889)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase VRK1(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50111373(CHEMBL3604889)
Affinity DataKi:  101nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed